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Tumor Microenvironment [electronic resource]
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Title Statement
  • Tumor Microenvironment [electronic resource]
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Publication, Distribution, etc. (Imprint)
  • Springer International Publishing : Imprint: Springer, Cham : 2020.
Edition Statement
  • 1st ed. 2020.
Physical Description
  • XXIV, 326 p. 61 illus., 56 illus. in color. online resource.
Series Statement
  • Cancer Treatment and Research, ISSN 0927-3042 ; 180
Formatted Contents Note
  • Preface -- Part I: Imaging of tumor microenvironment, In vivo Imaging -- New technologies to image tumors -- Part II: Immune landscapes and their biology, Systemic correlates of the tumor microenvironment -- Adaptive immunity and the tumor microenvironment -- The biology of immune active cancers and their regulatory mechanisms -- The biology of immune excluded cancers -- Immunoscore -- Part III: The tumor microenvironment and therapy, The Immune Landscape in Women Cancers -- Translational biomarkers, combination therapies and their relationship with immune landscapes -- Effects of radiation on the tumor microenvironment -- Challenges of CAR T cell therapy for solid tumors.
Summary, etc
  • This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Subject - Topical Term
  • Oncology  .
  • Immunology.
  • Oncology.
  • Immunology.
Added Entry - Personal Name
  • Lee, Peter P. editor. Utgivare, redaktör, sammanställare http://id.loc.gov/vocabulary/relators/edt
  • Marincola, Francesco M. editor. Utgivare, redaktör, sammanställare http://id.loc.gov/vocabulary/relators/edt
Added Entry - Corporate Name
  • SpringerLink (Online service)
Found in
  • Springer Nature eBook
Additional Physical Form Entry
  • Printed edition: ISBN 9783030388614
  • Printed edition: ISBN 9783030388638
  • Printed edition: ISBN 9783030388645
Series Added Entry - Uniform Title
  • Cancer Treatment and Research, 0927-3042 ; 180
ISBN
  • 9783030388621
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*24510$a Tumor Microenvironment$h[electronic resource] /$cedited by Peter P. Lee, Francesco M. Marincola.
*250  $a1st ed. 2020.
*264 1$aCham :$bSpringer International Publishing :$bImprint: Springer,$c2020.
*300  $aXXIV, 326 p. 61 illus., 56 illus. in color.$bonline resource.
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*490  $aCancer Treatment and Research,$x0927-3042 ;$v180
*505 0$aPreface -- Part I: Imaging of tumor microenvironment, In vivo Imaging -- New technologies to image tumors -- Part II: Immune landscapes and their biology, Systemic correlates of the tumor microenvironment -- Adaptive immunity and the tumor microenvironment -- The biology of immune active cancers and their regulatory mechanisms -- The biology of immune excluded cancers -- Immunoscore -- Part III: The tumor microenvironment and therapy, The Immune Landscape in Women Cancers -- Translational biomarkers, combination therapies and their relationship with immune landscapes -- Effects of radiation on the tumor microenvironment -- Challenges of CAR T cell therapy for solid tumors.
*520  $aThis book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
*650 0$aOncology  .
*650 0$aImmunology.
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*700  $aMarincola, Francesco M.$eeditor.$4edt$4http://id.loc.gov/vocabulary/relators/edt
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*950  $aMedicine (SpringerNature-11650)
*950  $aMedicine (R0) (SpringerNature-43714)
^
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